A groundbreaking new study reports that researchers were able to use gene therapy to eradicate HIV in mice. Now the team is considering how to turn that into a life-saving cure for humans.
"We actually have the tools now to go into the genome of a live animal — and inevitably into a person — and clip out, or excise out, the infectious HIV, in a means, or a pathway, towards a cure," said Howard Gendelman, a professor of internal medicine and infectious diseases at the University of Nebraska Medical Center, during an interview with Cheddar on Friday.
The treatment, which was discovered by teams at the University of Nebraska Medical Center and Temple University, works by "dampening down" the HIV virus through an antiretroviral therapy called LASER ART, and then using the gene-editing tool CRISPR-Cas9 — essentially a genetic "scissor" — to remove genes impacted by the virus.
The method led to a "total elimination" of the virus in nine of 23 animals, Gendelman said. It is the first time the virus has been completely eradicated from an animal, according to a UNMC press release.
But Gendelman cautions that applying the technique to humans requires both improving the technology for locating DNA impacted by the virus, and ensuring that the treatment doesn't damage other vital portions of the human genome.
"Every single HIV DNA that's integrated into the genome of a live host has to be excised. So we must develop even better technologies than we've developed in mice to discover where that latent virus is," explained Gendelman. "That's a major part of the research efforts ongoing now."
"We're manipulating the human genome. We're treating an HIV infection as if it was a genetic disorder. We're going into the genome and changing the structure, essentially using the HIV as a bad gene and cutting it out," he added. "So if we do that, we have to understand that there's a possibility that other genes can be affected."
More than 70 million people are reported to have been infected with HIV, according to the World Health Organization. The U.N. agency estimated that in 2017, more than 35 million people were living with the virus.
Communities of color are disproportionately affected by climate change and continuously feel the impacts. Mark Magaña, founding president and CEO of Green Latinos joined All Hands to discuss.
Neil Young has come up with an ultimatum for Spotify: his music or Joe Rogan’s podcast. This comes over concerns that the podcast is spreading COVID-19 vaccine misinformation to its listeners. "The Joe Rogan Experience," which is exclusive to Spotify, is currently the number one streamed podcast on the platform.
Commercial and residential buildings account for 13% of carbon emissions in the U.S., according to the EPA, and one company says it has a solution. Runwise says it has updated the boiler and heating systems of thousands of buildings, and that its technology not only lowers carbon output but also saves landlords money. Lee Hoffman, Co-Founder and COO of Runwise, joined Cheddar Climate to discuss.
Jo Ruxton, Founder of Ocean Generation, joins Cheddar Climate, where she explains the threat that plastic pollution poses to marine life, but elaborates on why we shouldn't be looking to ban plastic entirely. Ruxton also discusses her biggest takeaways while producing the film ‘A Plastic Ocean.'
President Joe Biden's Build Back Better deal seems all but finished after months of Democratic infighting and the Senate's deadlock over certain provisions. But Biden mentioned during a press conference marking his first year in office that 'chunks' of the bill could be passed. Is that enough motivation to force Democrats to rally around certain parts of the bill - especially those that focus on climate and green energy? Andrew Freedman, Energy and Climate Reporter at Axios, joins Cheddar Climate to discuss whether Senate Democrats will be able to rally around climate provisions, if the idea of passing Build Back Better in 'chunks' is doable, and more.
Anyone who remembers the 70s and 80s will probably remember acid rain. Industrial emissions acidified precipitation around the globe, which killed forests and crops, rendered lakes inhospitable, corroded buildings, and exacerbated human health problems.
But anyone who follows environmental news will be surprised to learn this: we solved it! Countries came together to limit acid rain-causing emissions, eliminating the problem altogether.
…kind of. Acidic precipitation may not be a thing of the past after all.
Natalie Ginsberg, Global Impact Officer, MAPS, joins Cheddar Reveals to discuss MAPS organization and its current initiatives and their work to get FDA approval for MDMA to treat PTSD.
Kelsey Ramsden, Co-Founder, President & CEO, Mind Cure Health, joins Cheddar Reveals to break down what 'psychedelic therapy' could look like once it's legalized and how Mind Cure Health is using AI to help treat everything from addiction to depression.
On this episode of Cheddar Reveals, Natalie Ginsberg, Global Impact Officer, MAPS, discusses the MAPS organization and its current initiatives and their work to get FDA approval for MDMA to treat PTSD; Kelsey Ramsden, Co-Founder, President & CEO, Mind Cure Health, breaks down what 'psychedelic therapy' could look like once it's legalized and how Mind Cure Health is using AI to help treat everything from addiction to depression; Cheddar gets a look at Curiosity Stream's 'Pain, Pus and Poison.'
