A groundbreaking new study reports that researchers were able to use gene therapy to eradicate HIV in mice. Now the team is considering how to turn that into a life-saving cure for humans.
"We actually have the tools now to go into the genome of a live animal — and inevitably into a person — and clip out, or excise out, the infectious HIV, in a means, or a pathway, towards a cure," said Howard Gendelman, a professor of internal medicine and infectious diseases at the University of Nebraska Medical Center, during an interview with Cheddar on Friday.
The treatment, which was discovered by teams at the University of Nebraska Medical Center and Temple University, works by "dampening down" the HIV virus through an antiretroviral therapy called LASER ART, and then using the gene-editing tool CRISPR-Cas9 — essentially a genetic "scissor" — to remove genes impacted by the virus.
The method led to a "total elimination" of the virus in nine of 23 animals, Gendelman said. It is the first time the virus has been completely eradicated from an animal, according to a UNMC press release.
But Gendelman cautions that applying the technique to humans requires both improving the technology for locating DNA impacted by the virus, and ensuring that the treatment doesn't damage other vital portions of the human genome.
"Every single HIV DNA that's integrated into the genome of a live host has to be excised. So we must develop even better technologies than we've developed in mice to discover where that latent virus is," explained Gendelman. "That's a major part of the research efforts ongoing now."
"We're manipulating the human genome. We're treating an HIV infection as if it was a genetic disorder. We're going into the genome and changing the structure, essentially using the HIV as a bad gene and cutting it out," he added. "So if we do that, we have to understand that there's a possibility that other genes can be affected."
More than 70 million people are reported to have been infected with HIV, according to the World Health Organization. The U.N. agency estimated that in 2017, more than 35 million people were living with the virus.
The Democratic governors of New Jersey, Connecticut, Delaware, and Oregon say they will lift mask requirements for schools in the coming weeks, reflecting a nationwide shift away from restrictions. Cheddar News speaks with internist Dr. Vivek Cherian whether it's safe to relax the regulation.
After months of investigation, board members from U.S. big oil companies were slated to appear before a House oversight committee this week to discuss their respective roles in pushing for climate initiatives internally. However, all four board members from Exxon, Shell, Chevron, and BP said they couldn't attend due to scheduling conflicts. Climate experts are testifying in their place about how effective big oil's climate promises have been so far. Meanwhile, President Joe Biden's lead science adviser Eric Lander has resigned after an investigation found he violated workplace policy. What will this mean for Biden's climate agenda? Amy Harder, executive editor of Cipher, a publication by Breakthrough Energy, joins Cheddar Climate to discuss.
Although this week's weather is predicted to be less severe than the 2021 storm, Texans are preparing for the worst - stocking up on supplies and emptying shelves in grocery stores, once again. Some Texans still have not recovered from last year's tragedy, and are heading into the next few weeks with anxiety for what's to come. Leslie Beyer, CEO of the Houston-based energy workforce & technology council, joins Cheddar News to discuss if the Texas grid will fail again.
The American Red Cross has declared its first-ever "national blood crisis" in the United States. Since COVID hit the U.S. in March 2020, blood donations have declined by 10 percent. American Red Cross Medical Director, Dr. Baia Lasky joined Cheddar News to discuss the country facing the worst blood shortage in over a decade. Dr. Lasky noted that as much as 40 percent of Americans are eligible to donate blood but only about 4 percent do so. "This is going to be ongoing," she said. "This is not an acute shortage. We really do need the commitment of people to come out and donate and donate again." Appointments to donate can be made by using the Red Cross Donor App, at RedCrossBlood.org, or calling 1-800-RED CROSS (1-800-733-2767).
Eight months after the National Football League announced $1 million in research into cannabinoids, the NFL-NFLPA Joint Pain Management Committee has awarded the funding to two teams of medical researchers at the University of California San Diego and the University of Regina. The NFL says the studies will investigate the effects of cannabinoids on pain management and neuroprotection from concussion in elite football players, respectively. Cheddar correspondent Chloe Ailello spoke with Jeff Miller, the executive vice president of communications, public affairs, and policy for the NFL, about the studies, as well as the recent lawsuit filed against the NFL by former Miami Dolphins head coach Brian Flores. "Maybe we can learn things from other alternative pain approaches that are going to benefit our player population and then sports medicine as a whole," Miller said.
On this episode of Cheddar Innovates: CEO of HereAfter AI discusses how artificial intelligence can be used to preserve family history and stories, and allow you to 'talk' to loved ones that have passed; Creator of the board game 'Travel Explore Discover' explains how she came up with the idea for this informative and educational board game, and how she's using the proceeds to give back to her community; Cheddar gets a look at Curiosity Stream's 'The Humboldt Current.'
Immunologist Dr. Purvi Parikh of the Allergy & Asthma Network joined Cheddar News to break down long Covid, in which Covid symptoms remain up to two years after infection; a phenomenon that has so far mystified health experts.
Solid-state battery maker Factorial Energy recently raised $200 million in a Series D round led by Mercedes-Benz and Stellantis. Factorial says the funding will be used to accelerate commercial production and deployment of its solid-state battery technology, which the company says is safer, and offers up to 50% more driving range than current lithium-ion technology. Factorial also has joint development agreements (announced in late 2021) with Mercedes-Benz, Stellantis, and Hyundai, three of the top 10 global automotive manufacturers, to commercialize its batteries. Factorial CEO Siyu Huang joined Cheddar News' Closing Bell to discuss.
David Malott, founder and chief architect at AI PlanetWorks joins Cheddar News to discuss the release of its augmented reality NFTs for the metaverse called 'TERA.'
