A groundbreaking new study reports that researchers were able to use gene therapy to eradicate HIV in mice. Now the team is considering how to turn that into a life-saving cure for humans.
"We actually have the tools now to go into the genome of a live animal — and inevitably into a person — and clip out, or excise out, the infectious HIV, in a means, or a pathway, towards a cure," said Howard Gendelman, a professor of internal medicine and infectious diseases at the University of Nebraska Medical Center, during an interview with Cheddar on Friday.
The treatment, which was discovered by teams at the University of Nebraska Medical Center and Temple University, works by "dampening down" the HIV virus through an antiretroviral therapy called LASER ART, and then using the gene-editing tool CRISPR-Cas9 — essentially a genetic "scissor" — to remove genes impacted by the virus.
The method led to a "total elimination" of the virus in nine of 23 animals, Gendelman said. It is the first time the virus has been completely eradicated from an animal, according to a UNMC press release.
But Gendelman cautions that applying the technique to humans requires both improving the technology for locating DNA impacted by the virus, and ensuring that the treatment doesn't damage other vital portions of the human genome.
"Every single HIV DNA that's integrated into the genome of a live host has to be excised. So we must develop even better technologies than we've developed in mice to discover where that latent virus is," explained Gendelman. "That's a major part of the research efforts ongoing now."
"We're manipulating the human genome. We're treating an HIV infection as if it was a genetic disorder. We're going into the genome and changing the structure, essentially using the HIV as a bad gene and cutting it out," he added. "So if we do that, we have to understand that there's a possibility that other genes can be affected."
More than 70 million people are reported to have been infected with HIV, according to the World Health Organization. The U.N. agency estimated that in 2017, more than 35 million people were living with the virus.
A new analysis reveals that for more than two decades, the West has been the driest it has ever been since 800 A.D. The drought which began in 2000 has brought more devastating wildfires and draining water reserves well below healthy levels. Climate Scientists and Adjunct Associate Research Scientist at Lamont Doherty Earth Observatory at Columbia University,Benjamin Cook, joined Cheddar to discuss more.
Energy Vault, the company developing sustainable, grid-scale energy storage solutions, is now trading on the New York Stock Exchange following the completion of its business combination with Novus Capital Corporation II. Energy Vault develops sustainable, grid-scale energy storage solutions designed to advance the transition to a carbon free, resilient power grid. Robert Piconi, co-founder and CEO of Energy Vault, joins Cheddar News' Closing Bell to disucss.
In an effort to fight climate change several corporations have vowed to work to fight climate change by 2030. They say the goal is to reduce carbon emissions by 40% or even close to 100%. However, according to a new study, many of these companies are not actually practicing what they preach. Tom Egger, senior lecturer at Emeritus at the University of Wisconsin, joins Cheddar News to discuss more.
At-home medical labs company Getlabs raised $20 million in a Series A round, led by Emerson Collective and the Minderoo Foundation. Getlabs aims to be the boots-on-the-ground partner to telehealth. The company says more than 70% of medical decisions still require collecting diagnostic tests in person, and that it fills that void by delivering health care directly to their patients' homes. Founder & CEO of Getlabs Kyle Michelson joined Cheddar News' Closing Bell to discuss.
Kalle Marsal, Chief Operating Officer at PetDx, joins Cheddar Innovates to discuss how next-generation sequencing technology is being used to detect cancer in pets early.
On this episode of Cheddar Innovates: WALDO CEO breaks down why now is a good time to make eyecare a priority, and how they are democratizing access to eyecare for all; COO at PetDx explains how next-generation sequencing technology is being used to detect cancer in pets early; Cheddar gets a look at Curiosity Stream's 'Inside The Mind of a Con Artist.'
Shares of Canadian cannabis giant Canopy Growth surged after the company reported Q3 earnings Wednesday morning, with shares up more than 15 percent at the close of the day's trading session. Despite net revenue declining year-over-year, Canopy beat analyst expectations and has ramped up efforts to develop a "THC ecosystem' in the U.S. Canopy Growth's CEO, David Klein, joined Cheddar News' Closing Bell to discuss the report. He noted that its brands Storz & Bickel vaporizers and BioSteel beverages showed record growth.
The Central Park Conservancy announced last month it has partnered with the Yale School of the Environment and the New York City-based Natural Areas Conservancy to study the on-the-ground impacts of climate change on urban parks. Salmaan Khan, Director of Research and Special Projects at the Central Park Conservancy joins Cheddar Climate to explain what factors put this initiative into motion and what data his team will be looking to uncover.
Energy Impact Partners is a VC firm committed to helping the world move toward a more sustainable future. The tech-focused fund aims to reach $350 million for its Deep Decarbonization Frontier Fund,' which aims to support early-stage companies working on innovative solutions. Energy Impact Partners' Managing Director Andy Lubershane joined Cheddar Climate to discuss.
Mukul Bakhshi, Chief of Strategy and Government Affairs for CGFNS International, joins Cheddar News to discuss strained U.S. hospitals seeking foreign nurses.
