*By Christian Smith*
After an overdose earlier this week, Demi Lovato's life was reportedly saved by Narcan, a nasal administrator of naloxone that counteracts the effects of opioids. When administered quicklyーthrough either nasal mist or injectionーnaloxone can temporarily halt an overdose, allowing EMTs enough time to respond. The medication is available without a prescription in 49 states, and the generic version costs about $20 per dose.
But all merits aside, is the drug's accessibility enabling addicts to push their limits?
Dr. Roger Crystal, the lead inventor of Narcan and CEO of Opiant Pharmaceuticals, says there's little evidence to support that concern.
"Addiction like any kind of chronic disease is something you can control using better medication, but ultimately you can't cure," Crystal told Cheddar. "To think about an opioid addict behaving rationally and saying, 'well because I have access to Narcan I'll shoot more heroin, inject more heroin' there's no proof for that whatsoever."
Naloxone is considered some of the best ammunition on the front lines of America's growing opioid epidemic. A reported 2 million Americans have an addition to opioidsーand the number isn't going down. U.S. Surgeon General Jerome Adams [issued an advisory](https://www.surgeongeneral.gov/priorities/opioid-overdose-prevention/naloxone-advisory.html) in April urging anyoneーand their close family and friendsーwho uses painkillers, heroin, fentanyl, or other opioids to carry naloxone in case of an emergency.
Crystal isn't stopping at Narcan: he told Cheddar he's also developing a heroin vaccine, suggesting the inventor has lofty ambitions for the future of overdose prevention.
Although Crystal may be aware of lingering ethical concerns, he doesn't think they dwarf his mission. After all, Lovato has him to thank.
"Putting it in the hands of everyone and anyone is critical," Crystal said.
For more on this story, [click here](https://cheddar.com/videos/how-one-pharmaceutical-company-is-fighting-the-opioid-epidemic).
Alysa McCall, director of conservation outreach and staff scientist at Polar Bears International, joined Cheddar to discuss the ongoing fight to protect polar bears from extinction while world leaders gathered to discuss the climate crisis. McCall explained her organization's mission "to ensure the long term survival of polar bears by helping ensure their arctic sea ice habitat remains intact." McCall said she hopes actionable steps are taken after the UN climate summit to mitigate the crisis and not just more promises.
Moderna reported a massive miss on revenue in its Q3 earnings, taking in $5 billion versus the expected $6.21 billion despite sales of the COVID-19 vaccine. The pharmaceutical giant's stock dropped sharply on the news.
Carlo and Baker discuss the fallout from Tuesday's election and the flashing warning sign for Dems ahead of the midterms. Also, a big 2A case at the Supreme Court, Aaron Rodgers has Covid and is in big trouble, and a first for the MCU.
Carlo and Baker discuss the election results across the country, including a Republican comeback in Virginia -- and possibly NJ -- plus the CDC gives the go-ahead for child vaccinations, Atlanta wins the World Series and more.
Dr. Julie Morita, executive vice president of Robert Wood Johnson Foundation, joined Cheddar to discuss the CDC advisory panel recommending the Pfizer vaccine for children ages 5-11. "We've seen many millions of children getting sick, many hospitalized, many dying because of COVID," Morita said. "And so now we have a new tool that we can use to keep our children safe." She also noted that hesitancy among parents about vaccinating their children will likely fade in time as the childhood vaccine program gets underway.
Matthew Oxenford, Analyst at the Economist Intelligence Unit, joins a special edition of Cheddar Climate, where he discusses the responsibilities big businesses across multiple sectors have when it comes to combating the effects of climate change around the world.
President Joe Biden introduced the Global Methane Pledge on the second day of the United Nations climate summit. The U.S. and the European Union will lead the way when it comes to methane emissions reductions, and close to 100 nations have also signed on. It's seen as the fastest way to slow down global warming and keep nations on track toward meeting the goal of keeping warming just 1.5 degrees Celsius above late 1800s atmospheric levels. Dr. Sweta Chakraborty, U.S. President of climate-focused startup 'We Don't Have Time' joins Cheddar Climate to discuss the importance of the Biden administration's methane regulations -- and the importance of U.S. leadership when it comes to climate issues.
John Paul Mejia, the national spokesperson for the Sunrise Movement, joined Cheddar to talk about what the youth activist group wants to see from President Joe Biden as he attends the COP26 climate summit. Mejia admonished the president for having little to deliver on his own climate agenda domestically while at the conference. "We need the president to follow through with his promises because, frankly, it's a matter of life or death not only for communities here in the United States but also those looking to us around the world," he said.
With COP26 kicking off, roughly 120 world leaders and delegates are in Glasgow, Scotland to hold climate talks this week. As experts continue to warn about the dangers of climate change, ESG investing is more important than ever.
Georges Archibald, Head of Apex Americas at Apex Group joined Cheddar's Opening Bell to discuss.
Roughly 20,000 heads of state, diplomats, and activists will gather in person starting Oct. 31 to address the threat of climate change. The summit, known as COP26, is seen as a crucial step in getting the crisis under control as scientists warn global warming is only getting worse. Carroll Muffett, President and CEO of the Center for International Environmental Law, joined Cheddar to explain the goals of COP26 and why it's so crucial for the world leaders to step up and make new, aggressive climate commitments.
