Would you volunteer to be deliberately infected with COVID-19? It's a question some people are seriously considering. In an effort to speed up the development of a vaccine, 1 Day Sooner is asking volunteers to sign up for human challenge trials that will expose them to the virus in an effort to study the disease and develop a cure.
Josh Morrison, the co-founder of 1 Day Sooner, told Cheddar Wednesday that these human challenges have been used to study other diseases in the past, including malaria, typhoid, and cholera.
"The drug Tamiflu, for example, was developed with challenge trials, as well as the malaria vaccine RTS,S that's being deployed in Africa right now," he said. "You can find out much more quickly whether a vaccine might work, than a traditional trial which might have thousands or even tens of thousands of volunteers."
The National Institutes of Health and the World Health Organization have shown interest in the human challenge trials, according to Morrison. The WHO recently published an ethics report to which the 1 Day Sooner team offered suggestions, though they were not accepted for the publication.
Morrison said that there has been growing interest in the trials, adding, "It's not universal acclaim or an immediate 'we need challenge trials right away from every possible corner,' but the message today is immensely different, immensely more positive than what the public message was a month ago."
He acknowledged that the risk of injecting people with COVID-19 could be deadly, but he said he believes that the potential value of finding a vaccine from these challenges is worth it.
"If you look at the risks of getting COVID-19 for the young, healthy group that would participate in challenge trials, they're roughly on a par with childbirth or with kidney donation. So, again, significant risk and we're not understating that, but these are risks that we commonly allow people to accept normally, and given the tremendous possible value we think it's worth accepting them in this case," the 1 Day Sooner co-founder said.
Jurors in the trial against Theranos CEO Elizabeth Holmes have entered day six of deliberations. Holmes is accused of lying to investors about the functionality of a newly developed blood-testing technology. Andrew George, partner at Baker Botts, joined Cheddar to break down key points in the case and what the jury might be considering during their deliberations. He also noted that the rest of Silicon Valley, including Holmes' business partner, Ramesh "Sunny" Balwani, who is facing identical charges, is closely watching the outcome of deliberations — as it could set the tone for future regulations and Balwani's own trial.
According to researchers, the state of California's cap-and-trade program is currently being undermined by forest fires caused primarily by climate change. Over the past few years, trees that were set aside for the program have been releasing carbon as they continue to burn in fires. Climate Researcher and Policy Director at CarbonPlan Danny Cullenward, joined Cheddar to discuss more.
The CDC's latest update to its COVID-19 quarantine guidelines reduces the isolation period from ten days to just five for people who test positive but are asymptomatic. Dr. Bayo Curry-Winchell, regional clinical director at Carbon Health, spoke to Cheddar's Baker Machado about the new guidance. She noted that while the reduced quarantine time "makes sense," the CDC should also require that a person test negative after their quarantine and before interacting with the public. "There is science behind it. We know that the majority of illness happens, or transmission, one to two days before the onset of symptoms and then two to three days as you have symptoms. So there is science behind the reducement of the actual five days," she said.
Prices at the pump this year reached a seven-year high, and a new forecast from GasBuddy shared with CNN predicts that gas prices will only continue to rise in 2022 and that the national average could even reach $4.00 a gallon; however, analysts at GasBuddy say anything could happen when it comes to gas prices in the future, as the pandemic has made it difficult to make any predictions about the economy. Consumer Energy Alliance federal policy advisor Michael Zehr joins Cheddar News' Closing Bell to discuss.
As the Omicron variant is fueling a surge in COVID-19 cases, parents and schools are faced with tough choices between absences and outbreaks. Matt Barnum, a national reporter at Chalkbeat, joins Cheddar News to discuss.
Ron Gutman, Co-CEO of Intrivo, joins Cheddar News to discuss how the company is creating a test and tech solution for Covid testing called 2Gather, and how it's using data-driven digital diagnostics to make these tests widely available and affordable.
As 2021 winds down, the number of positive COVID-19 cases has surged dramatically with numbers not seen since the heights of the pandemic. Dr. Laolu Fayanju, the regional medical director at primary care provider Oak Street Health, joined Cheddar to discuss the numbers, how the healthcare system is handling the surge this time around, and what it means that the CDC just cut the quarantine time guideline in half for those who are infected. "These are incredibly high numbers because they reflect the transmissibility of the omicron variant," Fayanju said.
