Would you volunteer to be deliberately infected with COVID-19? It's a question some people are seriously considering. In an effort to speed up the development of a vaccine, 1 Day Sooner is asking volunteers to sign up for human challenge trials that will expose them to the virus in an effort to study the disease and develop a cure.
Josh Morrison, the co-founder of 1 Day Sooner, told Cheddar Wednesday that these human challenges have been used to study other diseases in the past, including malaria, typhoid, and cholera.
"The drug Tamiflu, for example, was developed with challenge trials, as well as the malaria vaccine RTS,S that's being deployed in Africa right now," he said. "You can find out much more quickly whether a vaccine might work, than a traditional trial which might have thousands or even tens of thousands of volunteers."
The National Institutes of Health and the World Health Organization have shown interest in the human challenge trials, according to Morrison. The WHO recently published an ethics report to which the 1 Day Sooner team offered suggestions, though they were not accepted for the publication.
Morrison said that there has been growing interest in the trials, adding, "It's not universal acclaim or an immediate 'we need challenge trials right away from every possible corner,' but the message today is immensely different, immensely more positive than what the public message was a month ago."
He acknowledged that the risk of injecting people with COVID-19 could be deadly, but he said he believes that the potential value of finding a vaccine from these challenges is worth it.
"If you look at the risks of getting COVID-19 for the young, healthy group that would participate in challenge trials, they're roughly on a par with childbirth or with kidney donation. So, again, significant risk and we're not understating that, but these are risks that we commonly allow people to accept normally, and given the tremendous possible value we think it's worth accepting them in this case," the 1 Day Sooner co-founder said.
Experts say that at some point next year, the pandemic will officially drop its pandemic status, becoming endemic. While this is a milestone to acknowledge, it does not mean we're free of infections, illnesses, and deaths. Dr. Rajeev Fernando, infectious disease specialist, Beth Israel Hospital and fellow, joins Cheddar News' Closing Bell to discuss.
Chicago-based Internist Dr. Vivek Cherian joined Wake Up With Cheddar to break down the unprecedented surge in U.S. COVID-19 as many prepare to celebrate the new year.
Dr. Soumi Eachempati, co-founder and CEO of Cleared4 and former professor of surgery and public health at Weill Cornell Medical College, joined Cheddar to breakdown what people should know about the recently FDA-approved emergency use of Merck and Pfizer's COVID-19 treatment pills. He noted that not only do people need to be aware of other medications they are taking that could cause adverse effects if coupled with COVID-19 pill treatments, he also talked about the intense in-take regiment. "The Merck pills are actually about 40 pills over five days. The Pfizer ones are three pills over five days, so people have to be prepared for that because it is a lot of pills you'll have to take to get full value from these drugs," Eachempati told Cheddar.
Twitter is exploding with a new meme after the CDC revised its Covid-19 guidelines, shortening the recommended isolation period to five days instead of 10 for when you test positive and are asymptomatic. The change came amid a skyrocketing surge of new cases is the U.S. due to the Omicron variant, drawing criticism from experts and Twitter --with users claiming the government agency is giving funny advise on a variety of issues. But what does the meme say about the public’s trust in the agency? Cheddar News speaks with political strategist Hastie Afkhami.
The list of questions should be getting shorter as we enter the pandemic's third year, but that isn't the case. There's another question to add to that list: is the U.S. doing enough to track the virus and its variants? Lawrence Gostin, faculty director of the O'Neill Institute for national and global health law at Georgetown University, joins Cheddar News.
As we prepare to ring in the new year, COVID cases are hitting an all-time high. Dr. Anthony Fauci has said the safest way to celebrate would be a small gathering with vaccinated family members only... far from the large, flashy parties from a few years ago. Dr. Christina Johns, senior medical advisor at PM Pediatrics, joins Cheddar News to discuss how to celebrate safely.
